Sickle-cell disease is characterized by what type of red blood cells?

Sickle-cell disease is characterized by red blood cells that are shaped like a crescent or sickle. This abnormal shape arises due to a mutation in the hemoglobin gene, leading to the production of abnormal hemoglobin (known as hemoglobin S). When oxygen levels are low, these red blood cells become rigid and assume the sickle shape, which can cause blockages in blood vessels, leading to pain and serious complications. Unlike regular, oval, or round-shaped red blood cells that maintain a disc-like and flexible form, sickle-shaped cells have difficulty passing through small capillaries, affecting normal blood flow and oxygen delivery throughout the body. Understanding the significance of the sickle cell shape is crucial in recognizing the symptoms and implications of sickle-cell disease.